Mac's don't need defragging as OS X automatically writes 2Gb or below sized files to one contiguous space on the drive. There are certain cases where's it's needed to free up a large spaces on the drive, but not something everyone has to do.
Far as other Mac maintainence, there really isn't any except to backup one's files regularly. Keeping Software Updated and run a web browser check to make sure the plug-ins are current.
For Safari and Flash, this check is more accurate
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https://treecube394.weebly.com/download-chrome-mac-offline-installer.html. Most of those cleaning programs are junk, especially MacKeeper.
In short, a Mac cleaner software will help you intoxicate your Mac in every manner. Now that you have an idea, we will check out the best Mac cleaner software available right now. CleanMyMac X is the best Mac cleaning software. We had to use a number of Mac cleaning apps in order to find the best one. Best free antivirus for Mac: Avast Free Mac Securityavast.com Many antivirus suites provide a decent level of protection, but a few rise above all others by providing the very best in performance.
If your friend got onto your computer and visited a bunch of adult sites, then I would recommend something like OnyX, doing ALL the cleaning and maintenance aspects and rebooting, perhaps followed by a Disk Utility Erase free space.
CCleaner beta is out for OS X, used on PC's and combines cleaning and scrubbing of the drive if setup correctly.
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If your interested in performance, read my post here